Cupric sulfate yityuwa eyenziwe ngokunyanga cupric oxide nge sulfuric acid.Oku kwenza njengeekristale ezinkulu, eziluhlaza okwesibhakabhaka eziqulethe iimolekyuli ezintlanu zamanzi (CuSO4∙5H2O) kwaye yaziwa ngokuba yi-blue vitriol.Ityuwa engenamanzi yenziwa ngokufudumeza ihydrate ukuya kwi-150 °C (300 °F).